Precision public health is a new field of inquiry that applies genomics and other big data tools and technologies to the investigation and control of health threats in communities. A precision public health approach to COVID-19 requires rapid and iterative collection, analysis, and visualization of genomic, epidemiologic, geospatial, and contact tracing data. In most cases, these data include personally identifiable information (PII). For more information, or to register, go to: https://www.cdc.gov/genomics/events/microbetrace.htm